Sorafenib Cost in Usa is very expensive if you don’t have insurance. Sorafenib is a type of targeted therapy called a multikinase inhibitor. This means that it works by targeting receptors specific to cancer cells, thereby reducing the side effects caused by damage to healthy cells. Kinase is an enzyme that promotes cell growth. There are several types of kinases, which control different phases of cell growth. Sorafenib actually works by targeting two specific receptors, the Raf kinase and the VEGF receptors. Blocking Raf kinase slows cell division and tumor growth. VEGF receptors are responsible for angiogenesis, or the growth of new blood vessels by and for tumors, so blocking these receptors essentially attacks the tumor’s source of nutrients.
Cost of Sorafenib in Usa – How to Take Sorafenib
Sorafenib comes as a tablet to take by mouth. It is usually taken twice a day and should be taken on an empty stomach, 1 hour before or 2 hours after a meal. Take sorafenib at around the same times every day. If you forget to take a dose, skip the missed dose and take the next dose at the scheduled time. Do not try to stop or double the next dose.
If we talk about Sorafenib cost in Usa then it is quite very expensive. It is important to make sure that you are taking the correct amount of medicine each time. Before each dose, check that what you are taking matches the dose prescribed for you.
The blood level of this medicine may be affected by certain foods and medicines, so these should be avoided. These include: warfarin, carbamazepine, rifampin, phenytoin, St John’s wort and phenobarbital. Be sure to tell your healthcare provider about all the medicines and supplements you take.
Storage and Handling
Store your medicine in the original, labeled container at room temperature and in a dry place (unless directed otherwise by your healthcare provider or pharmacist). This medicine should not be stored in a pillbox. Keep containers out of reach of children and pets.
If a caregiver prepares the dose for you, they should consider wearing gloves or pour the pills directly from their container with the cap, into a small cup, or directly into your hand. They should avoid touching the bullets. They should always wash their hands before and after giving you medicine. Pregnant or lactating women should not prepare supplements for you. Ask your oncology team where to return any unused medicine for disposal. Do not flush water down the toilet or throw it in the dustbin.
Where do I get this medication?
Sorafenib cost in Usa is only cheaper if we choose generic option. Sorafenib is available through select specialty pharmacies. Your oncology team will work with your prescription drug plan to identify an in-network specialty pharmacy for distribution and shipment of this medication directly to your home.
This drug may be covered under your prescription drug plan. Patient Assistance may be available to eligible individuals without prescription drug coverage. Co-pay cards, which reduce patient co-pay responsibility for eligible commercially (non-government sponsored) insured patients, are also available. If these resources are available, your care team can help you find them.
Possible Side Effects of Sorafenib
There are several things you can do to manage the side effects of sorafenib. Talk to your care team about these recommendations. They can help you decide what will work best for you. These are some of the most common or important side effects:
High Blood Pressure
This medicine can cause high blood pressure (hypertension). Patients should have their blood pressure checked weekly during the first 6 weeks of treatment and periodically thereafter. Any high blood pressure should be treated appropriately. Report any headache or dizziness to your provider.
Fatigue is very common during cancer treatment and is a feeling of extreme tiredness that usually does not go away with rest. For the period during and after cancer treatment, you may need to adjust your schedule to manage fatigue. Schedule time during the day to rest and save energy for more important activities. Exercise can help combat fatigue; A simple daily walk with a friend can help. Talk to your healthcare team for helpful tips on how to deal with this side effect.
Your oncology team may recommend medicines to relieve diarrhea. In addition, try eating low-fiber, bland foods, such as white rice and boiled or baked chicken. Avoid raw fruits, vegetables, whole grain breads, cereals and seeds. Soluble fiber is found in some foods and absorbs fluid, which can help relieve diarrhea. Foods rich in soluble fiber include: applesauce, bananas (ripe), canned fruit, orange slices, boiled potatoes, white rice, white flour products, oatmeal, cream of rice, cream of wheat and farina. Drink 8-10 glasses of non-alcoholic, non-caffeinated fluids a day to prevent dehydration.
Decrease in Appetite
Nutrition is an important part of your care. Cancer treatment can affect your appetite and, in some cases, side effects of treatment can make eating difficult. For help with food choices, ask your oncology care team about nutritional counseling services at your treatment center.
- Try eating five or six small meals or snacks throughout the day instead of three large meals.
- If you’re not eating enough, nutritional supplements can help. We need to know some other thing also before knowing Sorafenib cost in Usa.
- You may experience a metallic taste or feel that food has no taste at all. You may dislike foods or beverages that you enjoyed before receiving cancer treatment. These symptoms may last for several months or longer after treatment ends.
- Avoid any food that you think smells or tastes bad. If red meat is a problem, eat chicken, turkey, eggs, dairy products, and fish without strong odors. Sometimes cold food has less odor.
- Add extra flavor by marinating meat or fish in sweet juices, sweet and sour sauces or dressings. Use spices like basil, oregano, or rosemary to enhance the flavor. Bacon, ham and onions can enhance the flavor of vegetables.
Nausea and/or Vomiting
Talk to your oncology care team so they can prescribe medications to help you manage nausea and vomiting. In addition, dietary changes may help. Avoid things that may worsen symptoms, such as heavy or greasy/fatty, spicy or acidic foods (lemons, tomatoes, oranges). Use saline, or ginger ale, to ease symptoms.
Call your oncology care team if you are unable to drink fluids for more than 12 hours or if you feel lightheaded or dizzy at any time.
Hand Foot Syndrome
Hand foot syndrome (HFS) is a skin reaction that appears on the palms of the hands and/or soles of the feet as a result of certain chemotherapy agents being absorbed by the skin cells. HFS may begin as mild tingling, numbness, prickling and needles sensations, redness or pain, or swelling of the hands and/or feet. This can then progress to painful swelling, blisters or peeling of the skin that can interfere with your ability to carry out normal activities. Be sure to tell your oncology team right away if you notice these symptoms, as they may need to adjust chemotherapy doses or take breaks to allow the skin to heal. Some tips to help prevent HFS include:
- Keep hands and feet clean and dry.
- Avoid tight shoes or socks.
- Avoid activities that put pressure on the palms or soles for 1 week after treatment.
- Apply an alcohol-free moisturizer liberally and frequently. (Avoid moisturizers with perfumes or fragrances)
- Avoid very hot water for baths and showers.
Mouth Ulcers (Mucositis)
Some cancer treatments can cause sores or sores in your mouth and/or throat. Notify your oncology care team if your mouth, tongue, inside of your cheeks or throat become white, ulcerated, or painful. Regular oral care can help prevent or manage mouth sores. If cold sores become painful, your doctor or nurse may recommend painkillers. Sorafenib cost in Usa is not economical so patient prefers to buy it online.
- Brush twice a day with a soft-bristled toothbrush or cotton swab.
- Avoid mouthwashes that contain alcohol. A warm water mouth rinse with baking soda and/or salt (2 teaspoons of baking soda or 1 teaspoon of salt in an eight-ounce glass of warm water) up to 4 times daily is recommended.
- If your mouth is dry, eat moist food, drink plenty of fluids (6-8 glasses), and suck on sugarless hard candy.
- Avoid smoking and chewing tobacco, drinking alcoholic beverages and citrus fruit juices
Skin and Nail Changes
Rash, very dry skin or itchy skin may occur in some patients. Use an alcohol-free moisturizer on your skin and lips; Avoid moisturizers with perfume or fragrance. If the itching is bothersome, your doctor or nurse may recommend a topical medicine. Your nails may turn black, brittle, or fall off. If your skin breaks or bleeds or one of your nails breaks, be sure to keep the area clean to avoid infection. While receiving this medicine, the hair on your head may become frizzy, thin, or brittle. You may experience hair loss or thinning. It gets better after stopping the treatment.
Be sure to notify your healthcare provider if any rash develops, as this could be a reaction and can be serious. This includes blistering and peeling on your skin or inside your mouth. They can give you more tips on taking care of your skin, hair and nails.
Less common, but important side effects can include:
- Wound Healing: This medication can lead to slower or incomplete wound healing, such as a surgical wound not healing or staying closed. Be sure to inform the team performing the surgical procedure that you are taking sorafenib. You should also inform your oncology team that a surgical procedure is planned. It is recommended that this medication be discontinued at least 10 days prior to any surgery. In addition, you should wait 2 weeks after surgery and any surgical incision should be fully healed prior to starting or restarting the medication. If you have a surgical wound that has not healed or begins to have signs of infection (redness, swelling, warmth), report this to your healthcare team.
- GI Tear: This medication can cause a tear in the intestinal wall, also called a gastrointestinal perforation. Signs of this can include: new or worsening pain in the abdomen, new abdominal swelling, chills, fever, constipation, nausea, or vomiting. If you experience any of these, contact your healthcare provider immediately or go to the emergency room.
- Heart Rhythm Changes: This medication can cause slow or abnormal heartbeats or an abnormal heart rhythm called QT prolongation. Notify your oncology care team right away if you feel abnormal heartbeats or if you feel dizzy or faint.
- Bleeding, Stroke, Heart Attack: Sorafenib can increase the risk of blood clots, stroke, and heart attack. Symptoms can include: swelling, redness or pain in an extremity, chest pain or pressure, pain in your arm, back, neck or jaw, shortness of breath, numbness or weakness on one side of the body, trouble talking, confusion or mental status changes. If you experience any of these symptoms, you should contact your oncology care team immediately or go to an emergency room.
- TSH Levels in Thyroid Cancer Treatment: Patients with thyroid cancer may need to have their TSH levels monitored more frequently while on this medication.
- Drug Induced Hepatitis: This medication can cause liver failure, which your oncology care team may monitor for using blood tests called liver function tests. Notify your healthcare provider if you notice yellowing of the skin or eyes, your urine appears dark or brown, or you have pain in your abdomen, as these can be signs of liver toxicity.
- Blood Counts:Your blood counts can be affected by this treatment, though the effect is usually mild. This can cause lower numbers of the following cells:
- White blood cells (WBC): important for fighting infection. You should let your doctor or nurse know right away if you have a fever (temperature greater than 100.4°F/38°C), sore throat or cold, shortness of breath, cough, burning with urination, or a sore that doesn’t heal.
- Red blood cells: responsible for carrying oxygen to the tissues in your body. You should let your doctor or nurse know if you experience any shortness of breath, difficulty breathing, or pain in your chest. If the count gets too low, you may receive a blood transfusion.
- Platelets: help your blood clot, so when the count is low you are at a higher risk of bleeding. Let your doctor or nurse know if you have any excess bruising or bleeding, including nose bleeds, bleeding gums, or blood in your urine or stool.
You must consult with your doctor also before checking Sorafenib cost in Usa. Exposure to this medicine may cause birth defects in an unborn baby, so you should not become pregnant or father a child while taking this medicine. A woman may need to undergo a pregnancy test before taking this medicine. Effective birth control is necessary during treatment and for at least 6 months after treatment for women and 3 months after treatment for men. Even if your menstrual cycles have stopped or you feel that you are not producing sperm, you can still be fertile and conceive. You should not breastfeed for 2 weeks after treatment ends. India is the best option to acquire it if you are looking cost of Sorafenib in Usa.